Table 2.
The distribution of glutathione S-transferase (GST) M1 and T1 genotypes in study groups
| Group | N-SCLC (%) ( n = 110) | Control (%) ( n = 100) | χ 2 | P value | OR ( CI 95%) |
|---|---|---|---|---|---|
| GSTT1 total | (n = 110) | (n = 100) | |||
| GSTM1(+) | 44 (40.0) | 58 (58.0) | - | - | - |
| (-) | 66 (60.0) | 42 (42.0) | 6.794 | 0.009 | 2.071 (1.194 to 3.593) |
| GSTT1(-) | (n = 75) | (n = 53) | |||
| GSTM1(+) | 24 (32.0) | 35 (66.0) | - | - | - |
| (-) | 51 (78.0) | 18 (34.0) | 14.480 | <0.001 | 4.132 (1.957 to 8.724) |
| GSTT1(+) | (n = 35) | (n = 47) | |||
| GSTM1(+) | 20 (57.1) | 23 (48.9) | - | - | - |
| (-) | 15 (52.9) | 24 (51.1) | 0.542 | 0.462 | 0.719 (0.298 to 1.734) |
| GSTM1 total | (n = 110) | (n = 100) | |||
| GSTT1(+) | 35 (31.8) | 47 (47.0) | - | - | - |
| (-) | 75 (69.2) | 53 (53.0) | 5.073 | 0.024 | 1.900 (1.084-3.331) |
| GSTM1(-) | (n = 66) | (n = 42) | |||
| GSTT1(+) | 15 (22.7) | 24 (57.1) | - | - | - |
| (-) | 51 (77.3) | 18 (52.9) | 13.177 | <0.001 | 4.533 (1.958-10.496) |
| GSTM1(+) | (n = 44) | (n = 58) | |||
| GSTT1(+) | 20 (45.5) | 23 (39.7) | - | - | - |
| (-) | 24 (54.5) | 35 (60.3) | 2.233 | 0.135 | 1.826 (0.826-4.036) |
| GSTM1/T1 | |||||
| (+/+) | 20 (18.2) | 23 (23.0) | - | - | - |
| (+/-) | 24 (21.8) | 35 (35.0) | 0.345 | 0.557 | 0.789 (0.357-1.743) |
| (-/+) | 15 (13.6) | 24 (24.0) | 0.542 | 0.462 | 0.719 (0.298-1.734) |
| (-/-) | 51 (46.4) | 18 (18.0) | 8.571 | 0.003 | 3.258 (1.457-7.287) |
+, present genotype; -, null genotype; OR, odds ratio; CI, confidence intervals.