Table 1.
The distribution of the Taq1B allele and genotype among CAD and controls, and P value of HWE in controls
| Sample size | B1 allele, % | B2 allele, % | B1B1 genotype | B1B2 genotype | B2B2 genotype | HWE, | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First author | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | P value |
| Arca M | 415 | 403 | 60.4 | 58.1 | 39.6 | 41.9 | 153 | 134 | 187 | 184 | 68 | 71 | 0.57 |
| Bhanushali AA | 90 | 150 | 59.4 | 50.3 | 40.6 | 49.7 | 33 | 37 | 40 | 76 | 17 | 42 | 0.820 |
| Blankenberg S | 1214 | 574 | 60.8 | 57.2 | 39.3 | 42.8 | 407 | 175 | 644 | 303 | 149 | 93 | 0.047 |
| Corella D | 557 | 1180 | 62.4 | 63.6 | 37.6 | 36.4 | 224 | 482 | 247 | 537 | 86 | 161 | 0.557 |
| Dedoussis GV | 237 | 237 | 60.5 | 58.2 | 39.5 | 41.8 | 83 | 78 | 121 | 120 | 33 | 39 | 0.530 |
| Durlach A | 96 | 138 | -a | - | - | - | - | - | - | - | 13 | 39 | - |
| Eiriksdottir G | 388 | 794 | 59.1 | 52.6 | 40.9 | 47.4 | 128 | 194 | 191 | 396 | 59 | 155 | 0.072 |
| Falchi A | 100 | 100 | 58.5 | 56.0 | 41.5 | 44.0 | 30 | 30 | 57 | 52 | 13 | 18 | 0.581 |
| Freeman DJ | 498 | 1108 | 58.8 | 55.2 | 41.2 | 44.8 | 164 | 339 | 259 | 541 | 76 | 225 | 0.733 |
| Fumeron F | 608 | 724 | 60.0 | 59.5 | 40.0 | 40.5 | 209 | 258 | 312 | 346 | 87 | 120 | 0.826 |
| Horne BD | 3223 | 1588 | 57.5 | 56.0 | 42.5 | 44.0 | 1064 | 508 | 1579 | 762 | 580 | 318 | 0.293 |
| Hsieh MC | 101 | 264 | 42.1 | 29.7 | 57.9 | 70.3 | 19 | 23 | 47 | 111 | 35 | 130 | 0.920 |
| Izar MC | 386 | 604 | 40.1 | 43.0 | 59.9 | 57.0 | 32 | 66 | 238 | 374 | 107 | 145 | 0.000 |
| Jensen MK [HPFS] | 259 | 513 | 58.7 | 58.9 | 41.3 | 41.1 | 89 | 180 | 126 | 244 | 44 | 89 | 0.686 |
| Jensen MK [NHS] | 246 | 486 | 58.5 | 58.3 | 41.5 | 41.7 | 84 | 166 | 120 | 235 | 42 | 85 | 0.907 |
| Kaestner S | 204 | 35 | 53.9 | 60.0 | 46.1 | 40.0 | 53 | 13 | 114 | 16 | 37 | 6 | 0.778 |
| Kawasaki I | 24 | 361 | 79.2 | 53.6 | 20.8 | 46.4 | 15 | 101 | 8 | 185 | 1 | 75 | 0.565 |
| Keavney B | 4685 | 3460 | 57.7 | 56.9 | 42.3 | 43.1 | 1477 | 1100 | 2175 | 1527 | 790 | 646 | 0.005 |
| Kolovou G | 374 | 97 | 60.7 | 46.4 | 39.3 | 53.6 | 126 | 22 | 202 | 45 | 46 | 29 | 0.573 |
| Li J | 236 | 54 | 58.8 | 58.8 | 41.2 | 41.3 | 82 | 15 | 73 | 19 | 21 | 6 | 0.997 |
| Liu S | 384 | 384 | 58.1 | 56.9 | 41.9 | 43.1 | 125 | 122 | 196 | 193 | 63 | 69 | 0.628 |
| McCaskie PA | 556 | 2683 | 59.3 | 57.0 | 40.7 | 43.0 | 196 | 860 | 262 | 1328 | 93 | 485 | 0.482 |
| Meiner V | 577 | 659 | 57.1 | 52.6 | 42.9 | 47.4 | 173 | 166 | 282 | 320 | 95 | 134 | 0.383 |
| Mohrschladt MF | 116 | 184 | 56.9 | 54.9 | 43.1 | 45.1 | 36 | 57 | 60 | 88 | 20 | 39 | 0.642 |
| Muendlein A | 332 | 225 | 62.0 | 57.3 | 38.0 | 42.7 | 125 | 71 | 162 | 116 | 45 | 38 | 0.420 |
| Padmaja N | 504 | 338 | 58.5 | 49.3 | 41.5 | 50.7 | 163 | 86 | 264 | 161 | 77 | 91 | 0.386 |
| Park KW | 119 | 106 | - | - | - | - | 49 | 30 | - | - | - | - | - |
| Poduri A | 265 | 150 | 64.3 | 49.3 | 35.7 | 50.7 | 117 | 33 | 107 | 82 | 41 | 35 | 0.252 |
| Porchay-Balderelli I | 223 | 2901 | 63.9 | 59.5 | 36.1 | 40.5 | 95 | 1012 | 95 | 1431 | 33 | 458 | 0.198 |
| Qin Q | 249 | 167 | 58.8 | 58.4 | 41.2 | 41.6 | 81 | 49 | 131 | 97 | 37 | 21 | 0.012 |
| Rahimi Z | 207 | 92 | 62.3 | 50.0 | 37.7 | 50.0 | 57 | 20 | 144 | 52 | 6 | 20 | 0.211 |
| Rejeb J | 212 | 104 | 71.0 | 65.9 | 29.0 | 34.1 | 104 | 45 | 93 | 47 | 15 | 12 | 0.959 |
| Schierer A | 349 | 2082 | 47.0 | 49.0 | 53.0 | 51.0 | - | - | - | - | - | - | - |
| Tenkanen H | 72 | 226 | 54.2 | 55.5 | 45.8 | 44.5 | 19 | 64 | 40 | 123 | 13 | 39 | 0.125 |
| Van Acker BA | 792 | 539 | 59.4 | 58.1 | 40.6 | 41.9 | 275 | 171 | 391 | 284 | 126 | 84 | 0.06 |
| Wang SH | 111 | 75 | 58.6 | 56.0 | 41.4 | 44.0 | 38 | 22 | 54 | 41 | 19 | 12 | 0.327 |
| Wang W | 128 | 247 | 64.8 | 54.0 | 35.2 | 46.0 | 50 | 72 | 66 | 123 | 12 | 52 | 0.968 |
| Whiting BM | 3319 | 1385 | 58.1 | 56.7 | 41.9 | 43.3 | 792 | 280 | 1201 | 377 | 402 | 170 | 0.039 |
| Wu JH | 200 | 285 | 56.7 | 52.0 | 43.3 | 48.0 | 45 | 63 | 79 | 159 | 25 | 52 | 0.007 |
| Yan SK | 106 | 64 | 60.4 | 56.3 | 39.6 | 43.8 | 41 | 19 | 46 | 34 | 19 | 11 | 0.526 |
| Yang J | 83 | 163 | 62.7 | 52.1 | 37.3 | 47.9 | 31 | 47 | 42 | 76 | 10 | 40 | 0.401 |
| Yilmaz H | 173 | 111 | 59.0 | 55.5 | 41.0 | 44.5 | 66 | 39 | 72 | 46 | 35 | 26 | 0.093 |
| Zhang GB | 88 | 94 | 58.0 | 60.6 | 42.0 | 39.4 | 31 | 32 | 40 | 50 | 17 | 12 | 0.268 |
| Zhang YX | 334 | 301 | 67.7 | 65.1 | 32.3 | 34.9 | 174 | 136 | 104 | 120 | 56 | 45 | 0.034 |
| Zhao SP | 238 | 203 | 62.0 | 56.4 | 38.0 | 43.6 | 95 | 60 | 105 | 109 | 38 | 34 | 0.191 |
| Zheng KQ | 203 | 100 | 60.6 | 60.5 | 39.4 | 39.5 | 66 | 33 | 114 | 55 | 23 | 12 | 0.132 |
| Zhou DF | 47 | 330 | 57.4 | 68.0 | 42.6 | 32.0 | 17 | 157 | 20 | 135 | 10 | 38 | 0.280 |
| Total | 23928 | 27068 | 58.6 | 56.3 | 41.4 | 43.7 | 7533 | 7667 | 10910 | 11720 | 3634 | 4521 | |
HWE: Hardy-Weinberg equilibrium. The P value of HWE determined by the χ2 test or Fisher’s exact test in control groups; a: No data.