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. 2014 Nov 29;14:457. doi: 10.1186/1472-6882-14-457

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© Soliman et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Immunohistochemical staining of MMP-8 in liver. A and B, liver of CTR and CUR administered groups immunostained showing normal hepatic architecture with presence of a central vein (cv) and normal hepatic cords. C, liver of paracetamol intoxicated group showing increased expression of mmp-8 (arrow) in the necrotic area surrounding central vein (cv) together with leukocytic infiltration (neutrophils and lymphocytes; LI). D, liver of control negative paracetamol intoxicated group with no expression of mmp-8 in the necrotic area (N) around central vein (CV). E, liver of paracetamol intoxicated group treated with curcumin immunostained showing no expression of mmp-8 (arrows). Scale bar for photos from A to E is 100 μm. Inserts are high magnification fields in C, D and E with scale bars of 50 μm.