Table 2.
Clinical characteristics according to CD30-positive versus CD30-negative expression at diagnosis
| Characteristics | CD30-positive | CD30-negative | P-value |
|---|---|---|---|
| No. of patients | 30 | 66 | |
| Age at diagnosis (years) | 1.000 | ||
| ≤60 | 26 | 57 | |
| >60 | 4 | 9 | |
| Gender | 0.668 | ||
| Male | 20 | 41 | |
| Female | 10 | 25 | |
| ECOG PS | 0.428 | ||
| 0, 1 | 29 | 59 | |
| ≥2 | 1 | 7 | |
| Subtypes | 0.434 | ||
| UNKTL | 18 | 45 | |
| EUNKTL | 12 | 21 | |
| B-symptoms | 20 | 28 | 0.028 |
| Mass (diameter) ≥5 cm | 9 | 27 | 0.306 |
| Local tumor invasion | 21 | 40 | 0.375 |
| Extranodal sites ≥2 | 20 | 37 | 0.327 |
| Regional lymphadenopathy | 17 | 34 | 0.639 |
| Elevated serum LDH | 18 | 23 | 0.021 |
| Stage | 0.684 | ||
| I, II | 23 | 48 | |
| III, IV | 7 | 18 | |
| IPI score | 0.339 | ||
| 0, 1 | 16 | 42 | |
| ≥2 | 14 | 24 | |
| KPI score | 0.057 | ||
| 0, 1 | 11 | 38 | |
| ≥2 | 19 | 28 | |
| Treatment | 0.627 | ||
| Chemotherapy | 12 | 23 | |
| Chemotherapy + radiotherapy | 18 | 43 |
Abbreviations: ECOG PS Eastern Cooperative Oncology Group performance status, UNKTL upper aerodigestive tract NK/T-cell lymphoma, EUNKTL extra-upper aerodigestive tract NK/T-cell lymphoma, LDH lactate dehydrogenase, IPI International Prognostic Index, KPI Korean Prognostic Index.