Table 1.
Methodology projects
| Project title | Methodology area | Interviewee number* |
|---|---|---|
| Flexible parametric models | Statistical | 13 |
| Missing data for prognostics | Statistical | 13 |
| Multi-variable modelling, prognostic modelling | Statistical | 13 |
| Modelling the association between patient characteristics and change over time in a disease measure | Statistical | 3 |
| Combining multiple imputation and inverse probability weighting | Statistical | 3 |
| New measure of the predictive ability for a survival model | Statistical | 7 |
| Bias two-arm multi-stage trials | Statistical | 7 |
| Analysis of resources for trials | Statistical | 8 |
| Restricted mean survival time | Statistical | 4 |
| Multi-arm multi-stage trial design | Statistical | 5, 10 |
| Biomarkers | Statistical | 4 |
| Comparing dynamic treatment regimens or monitoring strategies | Statistical | 11, 12 |
| Estimating the effect of time-varying treatment or exposure on outcome | Statistical | 11, 12 |
| Developing guidance for researchers on patient and public involvement in clinical research | Trial conduct | 2 |
| Consumer involvement in MRC CTU studies | Trial conduct | 2 |
| DAMOCLES (DAta MOnitoring Committees: Lessons, Ethics, Statistics) | Trial conduct | 5 |
| Retention strategies for randomized trials | Trial conduct | 14 |
| Central monitoring techniques to replace on-site monitoring | Trial conduct | 6 |
| Risk-based monitoring of trials | Trial conduct | 9 |
| Analysis of subgroup interactions in individual patient data meta-analysis | Meta-analysis | 1 |
| Total | 20 | 14 |
*Interviewees 2, 3, 4, 5, 7, 11, 12 and 13 discussed more than one project. CTU, clinical trials unit; MRC, UK Medical Research Council.