Table 1.
WT | p47phox(−/−) | |||
---|---|---|---|---|
| ||||
vehicle | SMase | vehicle | SMase | |
TPT (ms) | 15.9 ± 1.1 | 15.5 ± 0.8 | 16.3 ± 1.0 | 15.3 ± 0.5 |
½ RT (ms) | 13.0 ± 0.8 | 12.6 ± 0.5 | 13.5 ± 1.0 | 13.3 ± 0.5 |
Max +dP/dt (N/cm2·s) | 284 ± 55 | 227 ± 38* | 315 ± 34 | 271 ± 48 |
(+dP/dt)/Pt (s−1) | 67 ± 2 | 68 ± 1 | 66 ± 2 | 67 ± 1 |
F50 (Hz) | 52 ± 2 | 60 ± 2* | 52 ± 3 | 57 ± 2 |
nH | 3.52 ± 0.13 | 3.89 ± 0.09 | 3.30 ± 0.09 | 3.95 ± 0.17† |
TPT, time to peak tension; ½ RT, on-half relaxation time; maximal rate of specific force development during twitch; Pt, peak twitch force F50, stimulus frequency that elicits 50% maximal force; nH, Hill coefficient (~ slope of force-frequency relationship). Pt force is shown in Fig. 3. Data are mean ± SE. For WT, n = 8 mice per group. For p47phox(−/−), n = 4 (vehicle) and n = 7 mice (SMase).
P < 0.05 vs. WT vehicle;
P < 0.05 vs. p47phox(−/−) vehicle