TABLE 2. INCIDENCE OF CAROTID ARTERY DISEASE BY SELECTED SUBGROUPS.
| Subgroup | Intervention | Comparison | HR* | (CI 95%) | P-Value** | ||
|---|---|---|---|---|---|---|---|
| N | % | N | % | ||||
|
| |||||||
| Main Effect | 123 | (0.08) | 174 | (0.07) | 1.08 | (0.85, 1.36) | 0.54 |
| Age (years) | 0.19 | ||||||
| 50 to 59 | 20 | (0.03) | 26 | (0.03) | 1.16 | (0.65, 2.10) | |
| 60 to 69 | 70 | (0.10) | 86 | (0.08) | 1.25 | (0.91, 1.71) | |
| 70 to 79 | 33 | (0.13) | 62 | (0.16) | 0.80 | (0.52, 1.23) | |
| Race/ethnicity | 0.26 | ||||||
| White | 105 | (0.08) | 161 | (0.08) | 0.99 | (0.77, 1.27) | |
| Black | 12 | (0.07) | 9 | (0.04) | 1.68 | (0.69, 4.06) | |
| Other | 6 | (0.05) | 4 | (0.02) | 2.20 | (0.62, 7.82) | |
| BMI | 0.85 | ||||||
| < 25 | 22 | (0.05) | 30 | (0.05) | 1.00 | (0.57, 1.75) | |
| 25 -< 30 | 49 | (0.09) | 64 | (0.07) | 1.18 | (0.81, 1.73) | |
| >= 30 | 52 | (0.09) | 79 | (0.09) | 1.00 | (0.70, 1.42) | |
| CEE alone Trial | 0.80‡ | ||||||
| Active | 8 | (0.16) | 9 | (0.11) | 1.51 | (0.58, 3.93) | |
| Placebo | 5 | (0.09) | 7 | (0.08) | 1.25 | (0.38, 4.10) | |
| No Randomized | 57 | (0.10) | 70 | (0.08) | 1.22 | (0.86, 1.73) | |
| CEE+MPA Trial | 0.38‡ | ||||||
| Active | 3 | (0.04) | 7 | (0.06) | 0.68 | (0.17, 2.75) | |
| Placebo | 7 | (0.09) | 7 | (0.07) | 1.48 | (0.51, 4.26) | |
| Not randomized | 43 | (0.06) | 74 | (0.06) | 0.87 | (0.59, 1.27) | |
| CaD Trial | 0.67‡ | ||||||
| Active | 24 | (0.06) | 37 | (0.06) | 1.05 | (0.63, 1.77) | |
| Placebo | 34 | (0.09) | 47 | (0.07) | 1.22 | (0.78, 1.91) | |
| Not randomized | 65 | (0.08) | 90 | (0.08) | 1.02 | (0.74, 1.40) | |
| % energy from fat at baseline (tertiles) | 0.50 | ||||||
| < 34.8% | 34 | (0.06) | 51 | (0.06) | 1.02 | (0.65, 1.59) | |
| 34.8-<39.4% | 40 | (0.07) | 61 | (0.07) | 0.90 | (0.60, 1.36) | |
| >= 39.4% | 48 | (0.09) | 60 | (0.08) | 1.22 | (0.83, 1.79) | |
| History of Carotid endarterectomy/ angioplasty | 0.004 | ||||||
| No | 115 | (0.07) | 169 | (0.07) | 1.02 | (0.80, 1.29) | |
| Yes | 8 | (3.18) | 5 | (1.29) | 13.95 | (1.63, 119.0) | |
| History of hypertension† | 0.07 | ||||||
| No | 23 | (0.03) | 43 | (0.04) | 0.76 | (0.46, 1.27) | |
| Yes | 96 | (0.14) | 118 | (0.12) | 1.29 | (0.98, 1.69) | |
| Smoking status | 0.38 | ||||||
| Never | 43 | (0.05) | 48 | (0.04) | 1.29 | (0.85, 1.96) | |
| Past | 65 | (0.10) | 97 | (0.10) | 1.02 | (0.74, 1.40) | |
| Current | 13 | (0.13) | 27 | (0.17) | 0.75 | (0.38, 1.46) | |
| Diabetes (treated) | 0.63 | ||||||
| No | 101 | (0.07) | 148 | (0.06) | 1.04 | (0.80, 1.34) | |
| Yes | 22 | (0.34) | 26 | (0.26) | 1.21 | (0.67, 2.17) | |
| History of statin use | |||||||
| No | 104 | (0.07) | 139 | (0.06) | 1.14 | (0.88, 1.48) | 0.23 |
| Yes | 19 | (0.20) | 35 | (0.25) | 0.78 | (0.44, 1.38) | |
| History of CHD (MI/CABG/PTCA) | |||||||
| No | 105 | (0.07) | 150 | (0.06) | 1.06 | (0.82, 1.36) | 0.23 |
| Yes | 16 | (0.46) | 18 | (0.34) | 1.67 | (0.82, 3.40) | |
| History of stroke | 0.33 | ||||||
| No | 120 | (0.08) | 166 | (0.07) | 1.09 | (0.86, 1.38) | |
| Yes | 3 | (0.20) | 8 | (0.33) | 0.47 | (0.09, 2.56) | |
*
Hazard ratio (95%CI) from a proportional hazards model stratified by age, hysterectomy status, prior history of carotid endarterectomy/ angioplasty, HT trial randomization group, CaD trial randomization group (time-dependent) and subgroup.
**
Corresponds to a significance test of the main effect or test of interaction or trend.
†
Self-report of hypertension or high blood pressure at baseline.
‡
Test of interaction does not include those not randomized.