Table 6.
Functional magnetic resonance imaging studies of emotional processing during HRT.
| Study | Subjects [STRAW stage] | Age (y) | Hormonal treatment | Technique | Test | Comparison | Results | Notes |
|---|---|---|---|---|---|---|---|---|
| RANDOMIZED CONTROLLED TRIAL | ||||||||
| Love et al., 2010 | 10 | 57 ± 1 | No HT (>3m): | fMRI | Emotion processing (positive, neutral, negative stimuli) | Placebo vs. HT | [Neg] | = Behavior |
| [S:≥+1B] | gr1: E+P (4w) + wash-out (4w) and placebo (4w) | HT: ↑ OFC, OC l, precG r, pC l | ||||||
| gr2: placebo (4w) + wash-out (4w) and E+P (4w) | Placebo: ↑dlPFC l, postcG r, daC | |||||||
| [Pos] | ||||||||
| Placebo: ↑ mFC l | ||||||||
| CROSS-SECTIONAL STUDIES | ||||||||
| Shafir et al., 2012 | 52 | 67 ± 6 | HT (within 2y of MP and ≥10y): | fMRI | Emotion processing (positive, neutral, negative stimuli) | NT vs. HT | n.s. | ↑ Time for picture rating in HT; |
| [S:≥+2] | 65 ± 5 65 ± 5 | gr1 (n = 15): CEE | NT vs. ET | NT: Pos–Neu: ↑ mFG l (BA10), aC (BA24+32) | ↑ Accuracy in current HT | |||
| ET: Neg–Neu: ↑entorhinal cortex r | ||||||||
| 65 ± 5 | gr2 (n = 20): CEE+P | NT vs. HT | NT: Pos–Neu: ↑Ins r | |||||
| gr3 (n = 17): NT | Current vs. past HT | Current HT: Pos–Neu: ↑HC r | ||||||
| Frey et al., 2010 | 11 | 51 ± 6 | / | fMRI | Emotion regulation | High- vs. low- emotional conflict resolution | High-conflict resolution: dlPFC (BA42+40+13+9+7+Pu+30+6+Cau+30+39) | ! No comparison group |
| [S:≥−2] | (40–60) | |||||||
See Appendix for acronyms/abbreviations.