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. Author manuscript; available in PMC: 2015 Mar 3.

Published in final edited form as: Chembiochem. 2014 Jan 23;15(4):595–611. doi: 10.1002/cbic.201300723

Effect of 4EGI-1 and its constrained indazole-based 4EGI-1 mimetic on mRNAs of cyclin D1, survivin, and p70S6K, whose expression was reduced in the presence of these analogs. Lysates of CRL-2813 cells that were incubated with the small molecules were analyzed by quantitative RT-PCR. The results from three independent experiments were calculated, and then were normalized to the levels of mRNA_18S. The data are shown as the means ±S.D. and analyzed using one-way ANOVA with Dunnett post-test. The significance in difference was assigned at a level of less than a 5% probability (P<0.05). mRNA_cyclin _D1/mRNA_18S, mRNA_survivin/mRNA_18S, and mRNA_p70S6K/mRNA_18S.

Inline graphic — Effect of 4EGI-1 and its constrained indazole-based 4EGI-1 mimetic on mRNAs of cyclin D1, survivin, and p70S6K, whose expression was reduced in the presence of these analogs. Lysates of CRL-2813 cells that were incubated with the small molecules were analyzed by quantitative RT-PCR. The results from three independent experiments were calculated, and then were normalized to the levels of mRNA_18S. The data are shown as the means ±S.D. and analyzed using one-way ANOVA with Dunnett post-test. The significance in difference was assigned at a level of less than a 5% probability (P<0.05). mRNA_cyclin _D1/mRNA_18S, mRNA_survivin/mRNA_18S, and mRNA_p70S6K/mRNA_18S.