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. Author manuscript; available in PMC: 2015 Mar 3.
Published in final edited form as: Chembiochem. 2014 Jan 23;15(4):595–611. doi: 10.1002/cbic.201300723

Table 2.

cLogP and IC50 values (μm) of selected compounds from the library of the constrained mimetics of 4EGI-1 in inhibition of cell proliferation assay by SRB in human melanoma CRL-2813.

Compound R1 R2 R3 cLogP SRB Assay
IC50 (μm) in
CRL-2813
1 (E)-4EGI-1 NO2 3,4-dichloro H 4.76 1.23±0.15
2 (Z)-4EGI-1 NO2 3,4-dichloro H 4.76 12.17±0.95
3 1a NO2 H H 3.99 5.65±1.77
4 1d NO2 3-OCH3 H 4.00 4.40±0.57