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A simplified schematic of the proposed pathways associated with AD pathogenesis. The red arrows indicate possible pathways whereby circadian dysregulation and poor sleep might promote AD pathogenesis through proinflammatory mechanisms and increased accumulation and deposition of Aβ. According to this model, bidirectional relationships exist between circadian dysregulation and poor sleep; inflammation and Aβ deposition; and AD pathogenesis and circadiandysregulation.
