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. 2014 Dec 1;27(10):543–550. doi: 10.1089/vim.2014.0080

FIG. 1.

FIG. 1.

Schematic diagram of the Middle East respiratory syndrome coronavvirus (MERS-CoV) S protein and location of the immunogens (rRBD and panel of peptides) used in this study. The codon-optimized full-length S coding gene was inserted into the expression vector pVRC. SP, signal peptide (residues 1–18); RBD, receptor-binding domain (residues 367–606); 751?, S1/S2 cleavage site; HR1, heptad repeat 1 (residues 992–1054); HR2, heptad repeat 2 (residues 1252–1286); TM, transmembrane domain (residues 1296–1353); rRBD, recombinant RBD from the Bac-to-Bac system (indicated by a gray box). The S peptides used in this study were SP2-1 (residues 509–530), SP2-2 (residues 529–554), and SP3 (residues 736–761) and are indicated by gray boxes.