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. 2014 Dec 1;30(10):847–853. doi: 10.1089/jop.2014.0021

FIG. 2.

FIG. 2.

Effect of tanibirumab on the formation of laser-induced CNV measured by Bandeiraea simplicifolia (BS) isolectin B4 labeling. (A) CNV areas of the RPE-choroid-sclera flat mounts were compared between tanibirumab-treated and control eyes. (B, C) On day 7, the mean CNV areas, as measured by BS isolectin B4 labeling, were significantly smaller in tanibirumab-treated eyes (20 and 60 μg/2 μL of PBS) (n=8 and 7, respectively) than in PBS-injected eyes (n=8; P=0.038 and P<0.001, respectively, by the Mann–Whitney U-test). There was no difference between human IgG-injected eyes and PBS-injected eyes. However, in eyes treated with 5 μg of tanibirumab (n=10), the mean CNV areas, as measured by BS isolectin B4 labeling, were not significantly smaller than in PBS-injected eyes (n=8; P=0.162 by Mann–Whitney U-test). *P<0.05. Scale bar denotes 100 μm.