Mean scores and standard error are presented for (A) WOMAC pain scores, (B) WOMAC stiffness scores, (C) WOMAC physical function score, and (D) WOMAC total scores for the high-rosA group (circles) and the control group (triangles). The change within groups from baseline to week 16 was examined; significant differences within the high-rosA group are indicated with a cross (+) and significant differences within the control group are indicated with an asterisk (*). rosA, rosmarinic acid; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.