Table 3.
Mechanisms of Analgesic Effect of A. muricata
| Duration of paw licking (sec) | Duration of paw licking (sec) | ||||
|---|---|---|---|---|---|
| Treatment | Dose | 0–5 min | % Inhibition | 15–30 min | % Inhibition |
| Vehicle | 10 mL/kg | 69.75±0.85 | 73.16±2.05 | ||
| A. muricata | 200 mg/kg | 83.00±7.38 | — | 17.00***±6.00 | 76.76 |
| Naloxone | 3+10 mL/kg | 67.4±9.66 | 3.37 | 76.25±4.88 | 0 |
| Naloxone+A. muricata | 3+200 mg/kg | 68.20±13.97 | 2.22 | 72.60γ±6.42 | 0.76 |
| Naloxone+morphine | 3+10 mg/kg | 80.00±5.08 | — | 70.30±5.36 | 3.91 |
| Glibenclamide+control | 10+10 mL/kg | 65.40±7.88 | 6.24 | 56.20±7.62 | 23.18 |
| Glibenclamide+diclofenac | 10+20 mg/kg | 66.80±13.67 | 4.22 | 78.80±6.58 | 0 |
| Glibenclamide+A. muricata | 10+200 mg/kg | 77.40±12.27 | — | 23.00**#±2.05 | 68.56 |
Values are expressed as mean±SEM; **P<.01, ***P<.001 versus vehicle-treated control; γP<.001 versus A. muricata 200 mg/kg treated; #P<.01 versus glibenclamide 10 mg/kg–treated group using one-way ANOVA followed by Tukey's post hoc multiple-comparison test.