Table 4.

Effect of Annona muricata Fruit Extract Against Hot-Plate-Induced Thermal Pain in Mice

		Reaction latency (sec)
Treatment	Dose	0 min	30 min	60 min	90 min	120 min
Vehicle	10 mL/kg	1.58±0.12	1.43±0.07	1.48±0.07	1.61±0.11	1.63±0.08
A. muricata	50 mg/kg	1.39±0.14	1.82±0.32	2.43±0.13	2.73*±0.13	1.56±0.07
			(5.02)	(12.10)	(15.52)	(1.97)
	100 mg/kg	1.64±0.14	2.67±0.30	2.81**±0.27	2.67±0.09	3.46***±0.71
			(12.30)	(14.04)	(12.27)	(21.72)
	200 mg/kg	1.26±0.14	3.82***±0.47	3.03**±0.43	2.83*±0.22	4.22***a±0.31
			(29.33)	(20.32)	(17.94)	(32.03)
Morphine	10 mg/kg	1.38±0.21	3.37***±0.48	3.78***±0.49	3.34***±0.12	3.90***±0.34
			(23.17)	(27.85)	(22.82)	(29.22)

Values are expressed as mean±SEM; ^*P<.05, ^**P<.01, ^***P<.001 versus vehicle-treated control; ^aP<.05 versus A. muricata 50 mg/kg, statistical level of significance by two-way ANOVA followed by Bonferroni post hoc multiple-comparison test. Values in parenthesis are % MPE.

MPE, maximum possible effect.