Table 5.
Effect of A. muricata Against Carrageenan-Induced Rat Paw Edema
| Change in paw circumference (cm) after treatment | |||||||
|---|---|---|---|---|---|---|---|
| Treatment | Dose | 1 h | 2 h | 3 h | 4 h | 5 h | 6 h |
| Vehicle | 10 mL/kg | 0.88±0.10 | 1.05±0.09 | 1.23±0.06 | 1.43±0.10 | 1.33±0.05 | 1.18±0.06 |
| A. muricata | 50 mg/kg | 0.56*±0.05 | 0.85±0.07 | 1.10±0.07 | 1.30±0.11 | 1.08±0.10 | 0.78±0.06* |
| 34.29 | 19.05 | 10.20 | 8.77 | 18.87 | 34.04 | ||
| 100 mg/kg | 0.45**±0.03 | 0.65**±0.03 | 0.80*±0.04 | 0.93*±0.03 | 0.66**±0.03 | 0.43**±0.05 | |
| 48.57 | 38.10 | 34.69 | 35.09 | 49.06 | 63.83 | ||
| 200 mg/kg | 0.45**±0.03 | 0.63**±0.05 | 0.73**±0.05 | 0.68**±0.11 | 0.43**±0.12 | 0.23***±0.10 | |
| 48.57 | 40.48 | 40.82 | 52.63 | 67.92 | 80.85 | ||
| Diclofenac | 20 mg/kg | 0.43**±0.09 | 0.63**±0.09 | 0.70**±0.07 | 0.73**±0.075 | 0.50***±0.058 | 0.35***±0.07 |
| 51.43 | 40.48 | 42.86 | 49.12 | 62.26 | 70.21 | ||
Values are expressed as mean±SEM; statistical level of significance *P<.05, **P<.01, ***P<.001 versus distilled water vehicle–treated group using two-way ANOVA followed by Bonferroni post hoc multiple-comparison test. Bold values indicate percentage inhibition of edema.