FIG. 1.

Culture devices and strategy. (A) Custom-made microwell arrays (scale bar represents 2 mm) and (B) schematic representation of cell seeding and division for analysis. (C) Static bioreactor for creating gradients (scale bar represents 10 mm). (D) Schematic cross section of the bioreactor depicting the different compartments with high and low glucose concentrations. The blue line depicts the height of the medium in the top compartment. The two white openings on both sides depict the in-/outlets. Color images available online at www.liebertpub.com/tea