FIG. 1.

Schematic of the trabecular region of interest (ROI) for three-dimensional (3D) bone morphometric analysis using microcomputed tomography (μCT). (A) Transverse and coronal views of a representative proximal tibia. (B) Using the epiphyseal plate (EP) as a reference level, quantitative analyses of trabecular bone morphometric parameters were performed using an ROI (delineated by the Skyscan CTAn software tool using freehand drawing depicted in white) starting immediately beyond the EP and extending 135 cuts/2-mm distally by transaxial tracing.