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. 2014 Oct 17;20(23-24):3212–3227. doi: 10.1089/ten.tea.2013.0663

FIG. 3.

FIG. 3.

Total body irradiation (TBI) significantly increases 3D bone morphometric parameters following bone marrow-derived mesenchymal stem/stromal cell (BMSC) transplantation in a cell dose-dependent fashion. Three-dimensional bone morphometric parameters of the proximal tibia marrow space 4 weeks post-transplantation (ROI: starting immediately beyond the epiphyseal plate and extending 2 mm distally by transaxial tracing for 135 cuts). (A–E) Nonirradiated and (F–J) irradiated animals. (A, F) Percent bone volume (BV/TV), (B, G) trabecular number (Tb.N), (C, H) trabecular thickness (Tb.Th), (D, I) trabecular separation (Tb.SP), and (E, J) bone mineral density (BMD; trabecular bone). Vehicle- and BMSC-transplanted tibiae at 1.32×105 (1%), 1.32×106 (10%), 6.60×106 (50%), or 1.32×107 cells/mL (100%) (***p<0.001 BMSC-transplanted vs. vehicle controls; ap<0.05, bp<0.01, cp<0.0001 1.32×105 cells/mL vs. higher doses; #p<0.05, $p<0.01, %p<0.0001 1.32×106 cells/mL vs. higher doses, n=7 animals per group).