FIG. 4.

TBI increases new bone formation in a cell dose-dependent fashion. Representative hematoxylin and eosin (H&E)-stained sections of the proximal tibia marrow space 4 weeks post-transplantation (ROI: starting immediately beyond the epiphyseal plate and extending 2 mm distally). (A–E) Nonirradiated and (F–J) irradiated animals. (A, F) Vehicle-transplanted (right) tibiae and BMSC-transplanted (left) tibiae at (B, G) 1.32×10⁵ (1%), (C, H) 1.32×10⁶ (10%), (D, I) 6.60×10⁶ (50%), or (E, J) 1.32×10⁷ cells/mL (100%) (EP: epiphyseal plate, M: marrow, T: trabecular bone, A: adipose tissue, C: cortical bone, 2.5×, scale bar 500 μm, 20×, scale bar 20 μm, n=7 animals per group). Color images available online at www.liebertpub.com/tea