Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Sick leave days
Systematic review	Mainly adults, mean age 28.2 years (range 13–75 years), suspected acute appendicitis based on disease history, clinical status, and laboratory findings 2 RCTs in this analysis	Duration of sick leave days with antibiotics with appendicectomy	Mean difference –0.69 days 95% CI –1.65 days to +0.27 days		Not significant
Systematic review	Adults with acute uncomplicated appendicitis (no abscess or phlegmon) 3 RCTs in this analysis	Duration of sick leave or disability with antibiotics with appendicectomy	Standard mean difference –0.19 95% CI –0.06 to –0.33 P = 0.005	Effect size not calculated	antibiotics