Table 2.

Effects of GLP-1 (7–36) vs. (9–36) on cardiac contractile function

	Time-Control	GLP-1 (7–36)	GLP-1 (9–36)
LV End Diastolic Volume (ml)
Baseline	78± 1	82 ± 3	78 ± 1
1.5 pmol/kg/min	75 ± 1	79 ± 4	71 ± 4
3.0 pmol/kg/min	75±3	79 ± 4	68 ± 5
10.0 pmol/kg/min	73±2	69 ± 4	66 ± 7
LCX Occlusion	75± 1	92 ± 5‡	76 ± 6
LV End Systolic Volume (ml)
Baseline	41±5	42±5	44±5
1.5 pmol/kg/min	40±6	41±5	46±4
3.0 pmol/kg/min	40±6	42±5	45±3
10.0 pmol/kg/min	36±6	34±4	43±4
LCX Occlusion	43±6	49±6	48±3
LV Stroke Volume (ml)
Baseline	37±5	40±3	34 ±4
1.5 pmol/kg/min	36±5	37±4	24±5
3.0 pmol/kg/min	36±6	37±4	23±5
10.0 pmol/kg/min	37±6	34 ±6	22±5
LCX Occlusion	32±6	48± 6‡	27±6
Cardiac Output (ml/min)
Baseline	2838±99	2531 ± 271	2324±529
1.5 pmol/kg/min	2689±74	2524 ± 331	1675±262
3.0 pmol/kg/min	2510±280	2676 ± 429	1558±201
10.0 pmol/kg/min	2474 ±255	2576 ± 575	1442±213
LCX Occlusion	2227±315	4319 ± 908†‡	1902±329
LV Ejection Fraction (%)
Baseline	48± 6	49 ± 5	44±6
1.5 pmol/kg/min	48±7	48 ± 5	34± 6
3.0 pmol/kg/min	48±8	48 ± 5	33± 6
10.0 pmol/kg/min	51±9	49 ± 6	33±6
LCX Occlusion	43±8	50 ± 6	35±6
End Systolic Pressure Volume Relationship (mmHg/ml)
Baseline	11±3	11±4	15±4
1.5 pmol/kg/min	16± 5	17±6	15±6
3.0 pmol/kg/min	17±5	17±4	14±3
10.0 pmol/kg/min	16±7	20 ±5	20±9
LCX Occlusion	12±4	13±3	13± 0
Volume Axis Intercept (ml)
Baseline	7 ± 2	9 ± 2	4 ± 4
1.5 pmol/kg/min	7± 2	9 ± 6	5 ± 3
3.0 pmol/kg/min	8 ± 2	19 ± 2‡	11 ± 5
10.0 pmol/kg/min	8±2	24 ± 4‡	7 ± 1
LCX Occlusion	9± 2	26 ± 8‡	9 ± 0
Tau ½
Baseline	43±7	42 ± 3	48 ± 13
1.5 pmol/kg/min	48±9	43 ± 4	52 ± 11
3.0 pmol/kg/min	44±8	44 ± 5	55 ± 14
10.0 pmol/kg/min	64± 13	45 ± 8	63 ± 17
LCX Occlusion	60± 14	32 ± 3	83 ± 27

Values are mean ± SE for Time-Control (n = 5), GLP-1 (7–36) (n = 5) and GLP-1 (9–36) (n = 5).

^†P < 0.05 vs. baseline value (same treatment).

^‡P < 0.05 vs. infusion rate matched, saline infused time controls.