Table 3.

Disease-free survival in validation cohort C (HER2-positive patients, n=290) in the multivariate Cox regression analysis

Parameter	Cohort C (n=290)
	Hazard ratio	95% CI	P-value
uPA mRNA (Q4 versus Q1–3)	2.86	1.36–6.01	0.006*
PAI-1 mRNA (>median)	1.85	1.01–3.42	0.048*
Tumor size (<2 cm)	0.43	0.23–0.78	0.006*
Grade (G3)	1.10	1.04–1.18	0.003*
Nodal status (positive)	1.16	0.61–2.23	0.652
ER status (positive)	0.55	0.29–1.06	0.072

Note:

^*Statistically significant.

Abbreviations: CI, confidence interval; ER, estrogen receptor; uPA, urokinase plasminogen activator; PAI-1, plasminogen activator inhibitor.