Table 2. Factors associated with survival over three years after Combined Ablation and Resection (CARe) for Extensive Colorectal Liver Metastases.

	Hazard Ratio	95% confidence interval	P
Overall survival at three years
Presence of complications
Yes	1.80	1.16–2.76	0.008
No	1 (Reference)
Existence of extra hepatic metastases
Yes	2.01	1.03–3.94	0.041
No	1 (Reference)
Local recurrence-free survival at three years
Maximum size of the lesion
<1 cm,	1 (Reference)		0.071
1–3 cm	2.88	0.68–12.13	0.151
≧3 cm	5.58	1.14–27.23	0.034
Hepatic recurrence-free survival at three years
Bilateral liver metastases
Yes	2.10	1.12–3.89	0.019
No	1 (Reference)
Presence of complications
Yes	1.40	1.03–1.90	0.035
No	1 (Reference)
Number of metastases treated by intra-operative ablation
≧2	1.40	1.03–2.00	0.033
<2	1 (Reference)
Progression-free survival at three years
Synchronous liver metastases
Yes	1.57	1.12–2.19	0.008
No	1 (Reference)
Presence of complications
Yes	1.40	1.05–1.86	0.022
No	1 (Reference)
Pre-operative targeted therapy
Yes	1.41	1.05–1.88	0.021
No	1 (Reference)