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. 2014 Dec 8;9(12):e114537. doi: 10.1371/journal.pone.0114537

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© 2014 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, Synapse-driven spikes were elicited with a similar latency as EPSPs. B, Representative traces showing the adaptation of synapse-driven spikes in response to extracellular current stimulation. C, Sample traces of an EPSC (left) and IPSC (right) from two pairs of cortical neurons stimulated at 10 Hz and recorded using dual patch-clamp techniques. D, Normalized postsynaptic current amplitude plotted against stimulus number (n = 27 for EPSC and n = 14 for IPSC).