Figure 2. Location of HSV-specific, tissue-resident ASCs in guinea pigs infected previously with HSV-2.

Hartley guinea pigs were infected ivag with HSV-2 strain MS and lymphocytes isolated from the indicated tissues on days 48–57 post infection. HSV-specific ASCs were quantified by ELISPOT on HSV-2 glycoprotein-coated plates. Each data point represents results from an individual animal. (* P<0.05; ** P<0.01, Student's t test).