Figure 7. Presence of CD4⁺ and CD8⁺ HSV-specific memory T cells in genital tracts and neural tissue of HSV-2 infected guinea pigs.

Hartley guinea pigs were infected ivag with HSV-2 strain MS and lymphocytes isolated from the indicated tissues on days 99–150 post infection. Enriched populations of CD4⁺ and CD8⁺ T cells were obtained using a magnetic-based kit. HSV-specific, IFN-γ SCs were detected and quantified by IFN-γ ELISPOT. Each data point represents results from an individual animal. (* P<0.05 Student's t test).