Table 1. Activated upstream regulators of the “common” Core OB-BMST.
| Gene Symbol | Gene Name | Fold Change | Molecule Type | Activation z-score | p-value of overlap | Target molecules in dataset |
| Tgfβ1 | transforming growth factor, beta 1 | growth factor | 3.47 | 3.54E-12 | Abca1,Anpep,Arf4,Bmp1, Cav2,Cdc,Cnn3,Col16a1, Ece1,Elk3,Fermt2, Fscn1,Gfap,Gns,Hes1,Hexb,Hey1,Jup,Ltbp3,Mboat2, Mphosph9,Mybl2,Myof,Nab2,Nos3,Nupr1,Olr1,Pdlim4, Plat,Plk2,Plod1,Plscr1,Pold1,Prim1,Rad51ap1,Ramp2, Serpine2,Ski,Slc39a1, Smad6,Snai1,Tgfβr1,Tgfβr2,Tyms,Zwint | |
| Ephb4 | EPH receptor B4 | 3.1 | kinase | 2.00 | 9.51E-04 | Smad6,Tek,Tgfβr1,Tgfβr2 |
| Kdm5b | lysine (K)-specific demethylase 5B | transcription regulator | 2.00 | 2.03E-02 | Hmmr,Ncaph,Recql,Smc5 | |
| Nupr1 | nuclear protein, transcriptional regulator, 1 | 6.97 | transcription regulator | 2.12 | 3.44E-02 | B3gnt5,Brcc3,Gch1,Gk, Gtse1,Mms22l,Nupr1,Spag5,Stil |
| Igf1r | insulin-like growth factor 1 receptor | transmembrane receptor | 2.00 | 3.70E-02 | Nos3,Plat,Prkcdbp,Snai1, Tyms | |
| Fgf2 | fibroblast growth factor 2 (basic) | growth factor | 2.35 | 8.39E-02 | Anpep,Efnb2,Gfap,Nos3, Plat,Snai1 |