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. 2014 Dec 8;9(12):e114027. doi: 10.1371/journal.pone.0114027

Table 1. Age-adjusted mortality rates (per 100,000, world standard), for all causes and specific causes, and Annual Percent Changes (APC) between Join Points (JP) in Italian males (A) and females (B) aged 0–49 years during the period 1901–2008.

Causes of death 1901–2008 APC Start (year) APC1 (95% CI) 1st JP (year) APC2 (95% CI) 2nd JP (year) APC3 (95% CI) 3rd JP (year) APC4 (95% CI) End (year)
A. Males
ALL −3.2* 1318.3 (1901) −1.7* (−1.9, −1.4) 661.2 (1946) −13.9* (−24.7, −1.5) 379.4 (1950) −3.1* (−3.2, −2.9) 60.9 (2008)
RESP −5.8* 278.2 (1901) −1.4* (−2.0, −0.8) 177.2 (1939) −7.9* (−8.2, −7.5) 1.9 (1993) −4.1* (−6.5, −1.6) 1.2 (2008)
DIG −5.0* 276.3 (1901) −1.0* (−1.6, −0.3) 262.7 (1922) −2.7* (−3.3, −2.1) 119.0 (1946) −13.3* (−16.4, −10.0) 34.9 (1954) −5.2* (−5.4, −5.1) 2.6 (2008)
INF −6.6* 268.0 (1901) −2.0* (−2.3, −1.8) 122.3 (1946) −16.8* (−24.3, −8.5) 48.8 (1951) −10.0* (−10.3, −9.7) 0.8 (1990) +2.0* (+1.0, +3.0) 1.0 (2008)
CV −1.4* 31.4 (1901) +0.9* (+0.2, +1.5) 45.1 (1918) −5.5* (−9.2, −1.5) 22.8 (1924) −0.6* (−0.8, −0.5) 19.9 (1966) −2.6* (−2.7, −2.4) 6.4 (2008)
CBV −1.7* 10.2 (1901) −0.7* (−1.0, −0.4) 7.5 (1929) −2.5* (−2.9, −2.1) 3.8 (1955) +0.2 (−0.2, +0.6) 3.9 (1980) −4.3* (−4.6, −3.9) 1.3 (2008)
TUM +0.5* 9.0 (1901) +0.8* (+0.7, +1.0) 14.4 (1949) +10.7 (−10.1, +36.2) 19.0 (1952) +0.9* (+0.5, +1.4) 23.3 (1977) −2.5* (−2.8, −2.3) 11.0 (2008)
ACC −0.6* 40.8 (1901) −0.1 (−0.3, +0.1) 37.0 (1941) +34.6* (+5.0, +72.7) 115.0 (1944) −22.3* (−39.4, −0.4) 47.6 (1947) −1.2* (−1.3, −1.1) 20.0 (2008)
END −0.2# 7.5 (1951) −4.9* (−5.2, −4.6) 1.8 (1983) +21.0* (+19.1, 23.0) 12.0 (1995) −30.7* (−38.6, −21.8) 3.5 (1999) −1.1 (−3.2, +1.1) 2.9 (2008)
NS −2.8#* 8.2 (1951) −1.0* (−1.8, −0.2) 6.9 (1963) −4.3* (−4.7, −3.9) 3.1 (1983) −1.5* (−1.7, −1.2) 1.9 (2008)
B. Females
ALL −3.9* 1292.9 (1901) −2.1* (−2.3, −1.9) 570.1 (1946) −12.1* (−17.9, −5.8) 281.1 (1952) −3.8* (−3.9, −3.6) 32.8 (2008)
RESP −6.2* 237.4 (1901) −1.7* (−2.4, −1.0) 138.2 (1940) −8.1* (−8.4, −7.8) 0.7 (2008)
DIG −6.2* 272.7 (1901) −2.1* (−2.4, −1.9) 111.1 (1945) −13.7* (−16.5, −10.8) 27.4 (1954) −7.7* (−8.0, −3.3) 2.3 (1988) −4.6* (−5.4, −3.8) 0.9 (2008)
INF −7.3* 293.0 (1901) −2.5* (−2.7, −2.3) 109.0 (1946) −18.3* (−22.3, −14.1) 24.7 (1953) −10.0* (−10.2, −9.7) 0.5 (1992) +1.9* (+0.8, +3.1) 0.5 (2008)
CV −3.0* 40.5 (1901) −1.2* (−1.4, −1.1) 22.0 (1949) −4.8* (−5.0, −4.5) 3.3 (1990) +3.1 (−2.1, +8.5) 3.7 (1996) −5.7* (−7.0, −4.4) 2.0 (2008)
CBV −1.9* 8.3 (1901) −1.1* (−1.3, −0.9) 5.0 (1946) −6.3* (−10.8, −1.7) 3.1 (1952) −1.2* (−1.4, −1.0) 2.0 (1994) −6.7* (−7.6, −5.7) 0.9 (2008)
TUM −0.1* 16.2 (1901) −0.2* (−0.3, 0) 15.8 (1945) +2.2* (+1.6, +2.9) 21.2 (1960) −1.0* (−1.2, −0.8) 16.8 (1987) −1.9* (−2.3, −1.6) 11.3 (2008)
ACC −1.1* 17.7 (1901) −0.5* (−0.8, −0.3) 14.6 (1946) −8.4 (−21.3, +6.7) 10.1 (1950) +0.3 (−0.3, +0.9) 11.0 (1976) −2.3* (−2.7, −1.9) 4.6 (2008)
END −2.0#* 6.2 (1951) −5.2* (−5.6, −4.9) 1.3 (1984) +13.5* (+11.1, +16.0) 4.4 (1995) −23.3* (−33.2, −11.9) 1.7 (1999) −1.6 (−4.1, +0.9) 1.6 (2008)
NS −3.2#* 6.4 (1951) −1.1 (−2.1, 0) 5.5 (1963) −4.9* (−5.4, −4.4) 1.8 (1984) −1.0* (−1.8, −0.1) 1.7 (1999) −4.2* (−5.8, −2.6) 1.9 (2008)

*P<0.05; #Period 1951–2008.