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. 2014 Dec 8;9(12):e114027. doi: 10.1371/journal.pone.0114027

Table 2. Age-adjusted mortality rates (per 100,000, world standard), for all causes and specific causes, and Annual Percent Changes (APC) between Join Points (JP) in Italian males (A) and females (B) aged 50–69 years during the period 1901–2008.

Causes of death 1901–2008 APC Start (year) APC1 (95% CI) 1st JP (year) APC2 (95% CI) 2nd JP (year) APC3 (95% CI) 3rd JP (year) APC4 (95% CI) End (year)
A. Males
ALL −0.9* 446.2 (1901) −0.6* (−0.6, −0.5) 259.6 (1984) −3.1* (−3.4, −2.8) 126.6 (2008)
RESP −2.9* 109.8 (1901) −1.5* (−1.9, −1.1) 62.9 (1939) −7.8* (−9.7, −5.8) 21.5 (1952) +1.9* (+0.5, +3.3) 37.3 (1969) −4.9* (−5.3, −4.6) 4.0 (2008)
DIG −1.0* 40.7 (1901) −2.7* (−4.0, −1.4) 27.8 (1913) −0.3* (−0.6, −0.1) 25.1 (1955) +1.0* (+0.4, +1.5) 29.5 (1978) −5.1* (−5.4, −4.8) 7.0 (2008)
INF −3.7* 36.4 (1901) −0.3* (−0.5, −0.1) 33.9 (1944) −4.2* (−5.0, −3.5) 12.7 (1963) −9.0* (−9.4, −8.6) 0.9 (1991) +5.2* (+4.3, +6.1) 1.9 (2008)
CV −0.5* 73.9 (1901) +0.9* (+0.2, +1.5) 91.2 (1918) −5.5* (−9.1, −1.7) 55.5 (1924) +0.8* (+0.7, +0.9) 85.3 (1977) −3.8* (−4.0, −3.5) 26.5 (2008)
CBV −1.8* 45.4 (1901) +0.6* (+0.5, +0.8) 55.8 (1931) −1.3* (−1.4, −1.1) 37.8 (1962) −2.2* (−2.5, −1.8) 22.9 (1981) −5.4* (−5.6, −5.2) 5.6 (2008)
TUM +1.2* 27.7 (1901) +0.8* (+0.6, +1.0) 36.5 (1929) +2.1* (+2.0, +2.3) 82.2 (1965) +1.0* (+0.7, +1.3) 101.9 (1988) −2.6* (−2.9, −2.2) 61.3 (2008)
ACC −0.6* 14.0 (1901) +0.7* (+0.5, +0.9) 29.4 (1945) −5.7 (−26.8, +21.5) 15.0 (1948) +0.5 (−0.1, +1.0) 18.2 (1972) −2.8* (−3.1, −2.5) 6.4 (2008)
END −0.9#* 11.8 (1951) −7.1* (−9.1, −5.1) 6.6 (1959) −1.8* (−2.5, −1.2) 5.3 (1978) +7.1 (−3.0, +18.3) 6.8 (1982) −1.0*(−1.4, −0.6) 5.6 (2008)
NS −0.8#* 5.6 (1951) −3.7* (−4.3, −3.2) 2.7 (1968) +0.6 (−0.1, +1.2) 3.4 (1985) −0.5* (−0.9, −0.1) 2.8 (2008)
B. Females
ALL −1.7* 402.8 (1901) −1.0* (−1.1, −0.8) 276.3 (1941) −2.1* (−2.2, −2.0) 65.7 (2008)
RESP −4.1* 89.4 (1901) −1.6* (−2.1, −1.1) 49.6 (1938) −9.0* (−11.3, −6.7) 12.3 (1952) −3.7* (−3.9, −3.4) 1.8 (2008)
DIG −1.6* 28.5 (1901) −3.2* (−3.8, −2.5) 10.1 (1924) +12.4 (−15.9, +50.1) 20.0 (1927) −1.4* (−1.5, −1.2) 8.3 (1986) −4.7* (−5.3, −4.8) 3.1 (2008)
INF −4.4* 28.9 (1901) −1.0* (−1.3, −0.8) 17.7 (1945) −12.0* (−16.8, −6.9) 6.5 (1952) −7.2* (−7.6, −6.9) 0.5 (1989) +5.5* (+4.4, +6.5) 1.0 (2008)
CV −2.0* 92.2 (1901) −0.9* (−1.0, −0.8) 60.9 (1957) −2.3* (−2.9, −1.8) 36.9 (1976) −4.3* (−4.5, −4.1) 8.4 (2008)
CBV −2.3* 32.5 (1901) +0.6* (+0.5, +0.8) 46.6 (1932) −1.1* (−1.5, −0.7) 39.5 (1950) −3.0* (−3.2, −2.9) 14.6 (1980) −5.6* (−5.8, −5.4) 3.2 (2008)
TUM +0.1* 33.6 (1901) +0.5* (+0.4, +0.6) 48.2 (1962) −0.1 (−0.4, +0.2) 47.8 (1987) −1.2* (−1.5, −0.8) 37.7 (2008)
ACC −0.4* 4.6 (1901) −0.1 (−0.4, +0.1) 3.9 (1950) +0.7* (+0.2, +1.2) 5.3 (1980) −3.4* (−3.9, −2.8) 1.9 (2008)
END −1.9#* 9.7 (1951) −4.5* (−6.3, −2.7) 7.1 (1960) +5.0 (−14.5, +29.0) 8.2 (1963) −1.4* (−1.8, −0.9) 5.7 (1987) −3.2* (−3.7, −2.7) 3.0 (2008)
NS −0.6#* 3.8 (1951) −5.6* (−7.6, −3.5) 2.5 (1958) −1.7* (−2.2, −1.2) 1.8 (1977) +1.7* (+0.2, +3.3) 2.2 (1987) −0.4 (−0.8, +0.1) 2.1 (2008)

*P<0.05; #Period 1951–2008.