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. 2014 Sep 9;5(20):9811–9822. doi: 10.18632/oncotarget.2443

Figure 6. HD-POL5551 reduces the GBM stem cell fraction in vivo and in vitro.

Figure 6

(A) Tumor tissue from each of the treatment groups was evaluated for endoglin (brown) and nestin (purple) expression. Nuclei were counterstained with methyl green. In the PBS and IgG and PBS and mcr84 groups, numerous nestin positive cells can be seen within the perivascular space (asterisks). In the HD-POL5551 and IgG and the HD-POL5551 and mcr84 groups, there are few to no nestin positive cells within the perivascular space. Nestin positivity is evident as punctate staining (arrowhead) rather than the usual diffuse cytoplasmic staining. Scale bar equals 20 microns. (B) CD133 fraction was measured by MACS in three different low passage isolates from GBM patients. Presented are the means and SEM of these measurements. * Indicates P<0.05 as determined by two-tailed t-test.