Figure 3. Oridonin suppressed tumor growth through antiangiogenic activity.

(A) The MTS proliferation assay of HCT116 (left panel) and the representative mice with tumor after treating with DMSO or Oridonin (right panel). (B) Photographs of DMSO and Oridonin treated group tumors, along with the graph of tumor weight. (C) The mean tumor size and the body weight of control and Oridonin groups. (D) Immunohistochemistry of tumor slides stained with antibodies against vWF and CD31; arrows showed new blood vessels in the tumor, with the statistical results of microvessels on the right. Mean integrated optical density (mean IOD) of blood vessels accords to the following formula: mean IOD = IOD/area of the tumor section. (**, P<0.01; ***, P<0.001).