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(A) DAPT blocked Notch gene transcription and Notch activity. (B) and (C) Oridonin remarkably inhibited expression of key ligands, receptors and downstream genes (Fig. 6B, Q-PCR) and proteins (Fig. 6C, Western blot) involved in the Jagged-Notch Signaling Pathway. (D) Schematic diagram of Oridonin inhibiting tumor growth and tumor metastasis by regulating the Jagged-Notch signaling pathway in HUVECs.
