Table 1. The top 40 up- and down-regulated genes in hMDMs infected by either wild type or an isogenic ankB L. pneumophila mutant strain compared to uninfected hMDMs at 8 h post-infection.
| Upregulated | Downregulated | ||||
| Gene | wild type | ankB | Gene | wild type | ankB |
| RANBP3L | 24.9558 | 26.77 | APOBEC3A | −2.1301 | −2.73152 |
| EGR1 | 20.546 | 24.0411 | GAPT | −2.03252 | −2.7872 |
| NR4A2 | 17.8068 | 18.0274 | ACAA1 | −1.68363 | −1.1802 |
| CCL20 | 12.9572 | 13.7933 | CD177 | −1.61745 | −1.56168 |
| RHCG | 12.7492 | 15.4015 | MIR186 | −1.61347 | −1.5868 |
| PMAIP1 | 11.8732 | 12.7965 | PSG3 | −1.57598 | 1.05404 |
| IL23A | 9.56236 | 12.0511 | MSL3L2 | −1.57256 | −1.37738 |
| GADD45B | 8.87087 | 10.1934 | LRRC25 | −1.57178 | −1.88843 |
| HES1 | 8.83049 | 10.3995 | CLEC4A | −1.5458 | −1.75417 |
| LIF | 8.79145 | 10.6728 | EFTUD1 | −1.53079 | −1.38747 |
| FOS | 8.7718 | 8.89375 | SNORD49A | −1.52728 | −1.37486 |
| CSF2 | 8.40756 | 10.9112 | INSIG2 | −1.50978 | −1.34251 |
| IL10 | 7.94675 | 8.5155 | LOC100133315 | −1.50807 | −1.19079 |
| CXCL2 | 7.55389 | 8.69098 | C5orf20 | −1.47832 | −1.60939 |
| IL12B | 7.53365 | 10.1927 | CMKLR1 | −1.47262 | −1.74118 |
| PTX3 | 7.49085 | 9.93165 | SNORD5 | −1.46528 | −1.4449 |
| IL6 | 7.41431 | 7.90096 | CD209 | −1.46377 | −1.05034 |
| TNF | 6.88512 | 7.34775 | C5orf44 | −1.45662 | −1.43777 |
| E2F7 | 6.83706 | 9.88067 | LOC221442 | −1.45215 | −1.4062 |
| IL20 | 6.72872 | 9.20687 | ZNF814 | −1.45034 | −1.44363 |
| CLCF1 | 6.67757 | 7.83769 | CLCN4 | −1.44066 | −1.44317 |
| LOC440896 | 6.5948 | 7.38741 | RAB42 | −1.43825 | −1.36904 |
| ZFP36 | 6.59423 | 8.02248 | C8orf44 | −1.43825 | −1.44839 |
| MIR155 | 5.77859 | 5.98857 | SUMO1P3 | −1.43729 | −1.04598 |
| GADD45A | 5.51276 | 7.40294 | RASA4 | −1.43024 | −1.74162 |
| KLF4 | 4.73673 | 5.55325 | MIR142 | −1.42423 | −1.76193 |
| CCL4 | 4.73258 | 5.05042 | ZNF573 | −1.42362 | −1.2825 |
| HIVEP2 | 4.64881 | 5.47726 | AKR1C3 | −1.42287 | −1.38282 |
| TNFSF9 | 4.61437 | 5.90509 | FCGR3A | −1.41971 | −1.44462 |
| FOSB | 4.53659 | 4.5787 | CLEC6A | −1.41775 | −1.48098 |
| NFKBIZ | 4.52984 | 6.05722 | ZNF846 | −1.41227 | −1.13047 |
| DENND4A | 4.46864 | 5.57978 | ZNF594 | −1.40638 | −1.70581 |
| NIPAL4 | 4.39544 | 5.99992 | CDKN3 | −1.40499 | −1.39675 |
| TFPI2 | 4.3389 | 4.61199 | LYPLAL1 | −1.40468 | −1.38222 |
| GEM | 4.29366 | 5.00829 | SNORD42B | −1.40304 | −1.61795 |
| IFNG | 4.21353 | 2.68894 | FPR3 | −1.40273 | −1.73894 |
| ZBTB10 | 4.17859 | 4.82323 | C5orf54 | −1.40168 | −1.88889 |
| OVOS | 4.17333 | 4.11822 | TRIM16 | −1.3968 | −1.37838 |
| CXCL3 | 3.99019 | 4.59161 | LOC344887 | −1.3964 | −1.44194 |
| GPR109B | 3.9855 | 5.21438 | SNORD96A | −1.3957 | −1.36989 |
Numbers indicate fold change.