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. 2014 Dec 4;159(6):1404–1416. doi: 10.1016/j.cell.2014.10.058

Figure S3.

Figure S3

Cardiovascular Effects of Altering Leptin Signaling in the DMH, Related to Figure 4

(A) 24hr heart rate (BPM) circadian rhythm in DIO mice on day 7 of leptin receptor antagonist (LRA) treatment into the DMH, compared to the baseline of DIO and lean mice. Mean ± SEM, n = 4-37

(B) 24hr systolic BP (SBP) (mmHg) circadian rhythm in DIO mice on day 7 of leptin receptor antagonist (LRA) treatment into the DMH, compared to the baseline of DIO and lean mice. Mean ± SEM, n = 4-37

(C) 24hr diastolic BP (DBP) (mmHg) circadian rhythm in DIO mice on day 7 of leptin receptor antagonist (LRA) treatment into the DMH, compared to the baseline of DIO and lean mice. Mean ± SEM, n = 4-37

(D) Representative image of GFP fluorescence, indicating AAV infection, to knockdown leptin receptor in the DMH of DIO mice. Virus had been injected 55 days prior to sacrifice of mice. Additional data for Figure 4.