Table 9.
Comparison of GRM3−/− mice and wild-types (WT) in laboratory tests of motor function.
| Task & measure | WT | GRM3−/− | Statistics |
|---|---|---|---|
| Horizontal Bar | |||
| Score/5 | 5 (5–5) | 5 (5–5) | U = 105; p = 0.756 |
| Accelerating Rotarod | |||
| Speed at fall (rpm) | 10.4 (9.03–14.1) | 9.8 (7.6–10.7) | U = 127.5; p = 0.534 |
| Latency to fall (s) | 24.6 ± 2.9 | 22.0 ± 2.8 | t < 1; p > 0.50 |
| Multiple Static Rods | |||
| Orientation Time (OT) | |||
| Average OT for rods 1–3 (s) | 8.7 ± 1.6 | 5.3 ± 0.5 | Main effect of group: F < 1; p > 0.50 |
| OT for rod 4 (s) | 4.9 ± 0.8 | 5.9 ± 1.0 | Main effect of rod: F(2,56) = 4.91; p = 0.011** |
| OT for rod 5 (s) | 9.8 ± 1.5 | 8.5 ± 1.7 | Group*rod interaction: F < 1; p > 0.30 |
| Transit Time (TT) | |||
| Average TT for rods 1–3 (s) | 21.9 ± 3.6 | 23.7 ± 3.1 | Main effect of group: F < 1; p > 0.80 |
| TT for rod 4 (s) | 21.3 ± 4.2 | 14.8 ± 2.1 | Main effect of rod: F(2,56) = 8.92; p < 0.001** |
| TT for rod 5 (s) | 34.5 ± 6.8 | 46.4 ± 14.4 | Group*rod interaction: F(2,56) = 113; p = 0.331 |
| Body Weight (g) | 27.8 ± 0.4 | 27.6 ± 0.4 | t < 1; p > 0.70 |
**p < 0.01. Horizontal bar and rotarod tests: parametric data are presented as mean ± SEM and were analysed with t-tests. Non-parametric data are presented as median (inter-quartile range) and were analysed with Mann–Whitney U-tests. Multiple Static Rods test: data are presented as mean ± SEM. OT and TT data were analysed using two-way Repeated Measures ANOVA on the log10 transformed data. n = 15 WT; n = 15 GRM3−/−.