Sustained CaMKII activity depending on βCaMKII.

A and B, representative ratio images (Aa and Ba) and time courses (Ab and Bb) of ECFP/Venus of VαC before and after the conditioning depolarization in PNs with additional transfection of βCaMKII (A) or αCaMKII (B). In Ab and Bb, the results obtained for Vα(T286A)C are also shown. n = 7 for each. C, time courses of the ECFP/Venus of VαC without (control) or with additional expression of mutant βCaMKII (T306/7D and K43R) or with nodularin (nod). n = 7 (control and nod) and 5 (T306/7D and K43R). D, ECFP/Venus ratio at 18 min of VαC, Vα(T286A)C, or CαV without (–) or with additional expression of αCaMKII, βCaMKII, mutant βCaMKII (T306/7D or K43R) or with nodularin (nod). n = 7 except for K43R or T306/7D (n = 5). **P < 0.01; *P < 0.05.