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. 2014 Oct 20;592(Pt 22):5079–5092. doi: 10.1113/jphysiol.2014.282079

Figure 7. GIRK2 is necessary for NPY-induced phase shifts in the molecular clock.

Figure 7

A, phase shifts of PER2::LUC rhythms in response to a 1 h treatment of 2.35 μm NPY or vehicle at CT 4 in WT and KO mice. *P < 0.05. B and C, representative bioluminescence traces from two WT (B) or two KO (C) SCN cultures treated with vehicle (black) or NPY (grey) for three cycles before and after treatment (top) or day 1 after treatment (bottom). Time 0: onset of NPY application. Predicted peak time, determined from 3 cycles post treatment, is indicated by vertical bars for each group. n = 6–8 cultures per group.