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. Author manuscript; available in PMC: 2014 Dec 8.
Published in final edited form as: J Autoimmun. 2012 Oct 27;40:122–133. doi: 10.1016/j.jaut.2012.09.003

Figure 2. Enhanced plasmin activation system in inflamed salivary glands.

Figure 2

MSG tissues from control subjects (n=5), pSS subjects with early/intermediate disease (n=6) and those with severe SS (n=5) were tested by RT-PCR for tissue plasminogen activator and two cell binding partners. A) RT-PCR for tPA revealed increased plasminogen activator expression in individuals with severe SS. Data (expression normalized to GAPDH) represent fold difference compared to non-SS MSG. B) Increased expression of annexin A2 was modest, but significant in the diseased tissues, and S100A10 was also significantly elevated in early/intermediate and severe disease relative to control (non-SS) tissues (C), *p≤0.01; **p=0.06, Mann-Whitney, two-tailed. D,E) Fraaser-Lendrum staining for fibrin in which fibrin, keratin, and some cytoplasmic granules appear red, erythrocytes appear orange, and matrix is green in MSG from a SS patient (FS=10); original magnification 20X and inset 40X (D) and normal MSG (20X) (E).