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. Author manuscript; available in PMC: 2014 Dec 8.
Published in final edited form as: J Autoimmun. 2012 Oct 27;40:122–133. doi: 10.1016/j.jaut.2012.09.003

Figure 4. IFN enhancement of tPA in vitro and elevated expression in vivo.

Figure 4

A) Monocytes were untreated (0), treated with IFNγ only (1–100ng/ml), treated with IFNα only (1–100ng/ml) or treated with IFNγ (1–100ng/ml) in the presence of IFNα (1–100ng/ml) and monitored by RT-PCR for tPA expression. B,C) By RT-PCR, MSG tissues from non-SS MSG, SS patients with early/intermediate disease and severe disease exhibited variable IFNα levels with progressive disease (B), whereas significant increases in expression of IFNγ were evident in early/intermediate disease and in severe disease (*p≤0.01) as compared to control non-SS tissues (C). P values calculated using Vassar Stats, Mann Whitney (two-tailed).