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. Author manuscript; available in PMC: 2014 Dec 8.
Published in final edited form as: J Autoimmun. 2012 Oct 27;40:122–133. doi: 10.1016/j.jaut.2012.09.003

Figure 5. Enhanced plasminogen activation by IFNγ in vitro and increased plasmin in vivo.

Figure 5

A) Monocytes were cultured in the presence or absence of IFNγ and tested for their ability to activate plasminogen resulting in plasmin formation as detected by proteolytic activity and cleavage of a colorimetric substrate (relative fluorescence units) over time, as indicated. B) Representative MSG tissues stained with an antibody to plasmin(ogen) reveal cell associated and intercellular positive staining within the inflammatory infiltrate, endothelial and ductal cells, relative to an isotype control antibody (C) and compared to control non-SS gland tissues (D). Original magnification 40X.