Table 4.
Change of patient characteristics by time period of enrollment
| Factor | Cohort, no. with factor/no. with valid data for factor (%) |
P | |||
|---|---|---|---|---|---|
| 1981 to 1987 | 1988 to 1992 | 1993 to 1998 | 1999 to 2002 | ||
| Male | 642/1120 (57) | 1855/3309 (56) | 1898/3339 (57%) | 619/1092 (57%) | .870 |
| Performance status 2+ | 532/1093 (49) | 1389/3229 (43) | 1274/2959 (43%) | 408/1047 (39%) | < .001 |
| ISS | |||||
| Stage I | 131/718 (18) | 639/2622 (24) | 794/2607 (30) | 226/829 (27) | < .001 |
| Stage II | 270/718 (38) | 1056/2622 (40) | 1004/2607 (39) | 345/829 (42) | .225 |
| Stage III | 317/718 (44) | 927/2622 (35) | 809/2607 (31) | 258/829 (31) | < .001 |
| Durie-Salmon stages I or II | 418/961 (43) | 1546/3052 (51) | 1278/2719 (47) | 427/999 (43) | < .001 |
| Stage I | 31/657 (5) | 195/2306 (8) | 182/2273 (8) | 86/932 (9) | .007 |
| Stage II | 83/657 (13) | 605/2306 (26) | 650/2273 (29) | 274/932 (29) | < .001 |
| Stage III | 543/961 (57) | 1506/3052 (49) | 1441/2719 (53) | 572/999 (57) | < .001 |
| Subtype A | 835/1117 (75) | 2671/3301 (81) | 2790/3310 (84) | 902/1072 (84) | < .001 |
| IgG | 559/1011 (55) | 1864/2969 (63) | 1799/3091 (58) | 631/1020 (62) | < .001 |
| IgA | 231/1011 (23) | 742/2969 (25) | 797/3091 (26) | 239/1020 (23) | .191 |
| IgD | 48/1011 (5) | 93/2969 (3) | 97/3091 (3) | 13/1020 (1) | < .001 |
| Light chain only | 138/1011 (14) | 229/2969 (8) | 333/3091 (11) | 124/1020 (12) | < .001 |
| Measurable M-protein | 894/1029 (87) | 2284/2603 (88) | 2686/3120 (86) | 831/1002 (83) | .002 |
| More than 3 lytic lesions | 388/854 (45) | 1258/2772 (45) | 1354/2834 (48) | 457/963 (47) | .264 |
| No bone lesions | 200/953 (21) | 659/2943 (22) | 684/3110 (22) | 213/994 (21) | .798 |
| β2M ≥3.5 mg/dL (≥0.2975 μM) | 515/724 (71) | 1674/2636 (64) | 1467/2790 (53) | 485/911 (53) | < .001 |
| Albumin <3.5 g/dL | 488/1084 (45) | 1308/3131 (42) | 1112/2828 (39) | 368/869 (42) | .010 |
| HGB <10 g/dL | 410/1093 (38) | 1267/3119 (41) | 1339/3263 (41) | 449/1064 (42) | .127 |
| Creatinine ≥2 mg/dL (≥176.8 μM) | 244/1103 (22) | 596/3175 (19) | 487/3249 (15) | 157/1046 (15) | < .001 |
| Platelets <(130 × 103) μL | 115/1084 (11) | 333/3133 (11) | 377/2918 (13) | 159/1033 (15) | < .001 |
| Calcium ≥10 mg/dL (≥2.5 mM) | 404/1053 (38) | 915/2791 (33) | 986/3020 (33) | 347/1006 (34) | .004 |
| CRP 0.8 mg/dL or more | 7/33 (21) | 312/1103 (28) | 529/1872 (28) | 251/732 (34) | .010 |
| Bone marrow plasma cells 33% or more | 665/1032 (64) | 1810/3049 (59) | 1832/3141 (58) | 570/1028 (55) | < .001 |
| LDH above normal | 63/195 (32) | 182/616 (30) | 491/1939 (25) | 152/615 (25) | .034 |
Where conventional units of measure are given in column 1, SI units follow in parentheses.