Table 2.
Summary of the CDF diffusion analysis results for tracked BRCA2-GFP particles in live Brca2GFP/GFP cells treated with 10 Gy IR (after 2 h), 1 µg/ml MMC (24 h), and 1 mM HU (1 h)
Damage | Type | D1 | A1 | D2 | A2 | D3 | A3 | σ |
µm2/s | % | µm2/s | % | µm2/s | % | µm | ||
Control | 1 (bound) | 0.59 | 10.7 | 0.037 | 37.9 | 0.002 | 51.4 | 0.009 |
2 (mobile) | 1.21 | 58.8 | 0.098 | 28.0 | 0.003 | 13.2 | 0.016 | |
IR | 1 | 0.81 | 6.7 | 0.038 | 38.0 | 0.002 | 55.3 | 0.009 |
2 | 1.41 | 42.6 | 0.079 | 33.0 | 0.003 | 24.4 | 0.014 | |
MMC | 1 | 0.75 | 6.8 | 0.031 | 42.0 | 0.002 | 51.2 | 0.008 |
2 | 1.39 | 43.7 | 0.047 | 34.2 | 0.002 | 22.1 | 0.009 | |
HU | 1 | 0.94 | 6.9 | 0.029 | 40.3 | 0.002 | 52.8 | 0.008 |
2 | 1.53 | 32.4 | 0.046 | 37.9 | 0.002 | 29.7 | 0.01 |