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. 2014 Dec 8;207(5):627–642. doi: 10.1083/jcb.201405105

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Figure 10. — Model of the regulation of DLC1 by CDK5. The upper part of model shows that DLC1 has a closed conformation with low Rho-GAP activity, weak tensin, and talin binding, as well as poor colocalization to focal adhesions, in the absence of Serine phosphorylation (S120, S205, S442, and S509) by CDK5. The lower part of the model shows that DLC1 has an open conformation with high Rho-GAP activity, strong tensin, and talin binding, and substantial colocalization to focal adhesions, in the presence of Serine phosphorylation by CDK5. The middle part of model indicates that activation of DLC1 can be inhibited by CDK5 inhibitors, CDK5 siRNA, or 4S-4A mutations of DLC1.