Table 1.
Properties of a ROS disc | Parameter value |
|
---|---|---|
Human | Mouse | |
Disc diameter | 1.17 ± 0.24 μm | 1.20 ± 0.25 μm |
Inner disc area | 0.74 ± 0.37 μm2 | 0.77 ± 0.39 μm2 |
Nanodomain height | 8.11 ± 0.21 nm | 8.10 ± 0.44 nm |
Lipid bilayer height | 3.68 ± 0.31 nm | 3.69 ± 0.28 nm |
Number of nanodomains | 156 ± 103 | 156 ± 99 |
Nanodomain density | 208 ± 79 μ−2 | 207 ± 79 μ−2 |
Mean nanodomain size | 1,109 ± 311 nm2 | 1,245 ± 379 nm2 |
Disc area occupied by nanodomains |
22 ± 8 % | 24 ± 9 % |
Number of rhodopsin molecules |
11,642 ± 7,108 | 13,513 ± 8,522 |
Rhodopsin spatial density | 15,865 ± 5,894 μm−2 | 17,486 ± 6,170 μm−2 |
Parameter values were determined from individual ROS disc membranes. The mean values are reported with the associated standard deviation. The mean was determined from the analysis of 50 human ROS disc membranes or 100 murine ROS disc membranes. Significant differences between human and mouse data was assessed by a t-test. No significant differences between parameters were observed (p > 0.05) except for the mean nanodomain size in a ROS disc membrane, where there is a small but significant difference (p = 0.03).