Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Lack of RTI-118 effects on in vitro activity mediated by a panel of 13 receptors and ion channels. ND=not determined.
| Receptor/Channel Target | Agonist EC50 | Antagonist IC50 |
|---|---|---|
| 5HT1A | > 10 μM | > 10 μM |
| 5HT2A | > 10 μM | > 10 μM |
| 5HT2B | > 10 μM | > 10 μM |
| hTAAR1 | > 10 μM | > 10 μM |
| CB1 | > 10 μM | > 10 μM |
| CB2 | > 10 μM | > 10 μM |
| Mu | > 10 μM | > 10 μM |
| Delta | > 10 μM | > 10 μM |
| Kappa | > 10 μM | > 10 μM |
| APJ (Apelin) | > 10 μM | > 10 μM |
| CaV 3.1 | ND | > 10 μM |
| CaV 3.2 | ND | > 10 μM |
| TRPV1 | > 10 μM | > 10 μM |
