Table 3.
HDAC inhibitors ongoing clinical trials
| Medication | Condition | Phase | Clinical Trial | Other drugs |
|---|---|---|---|---|
| Etinostat | Non-Small Cell Lung Cancer | Phase I/II Study | NCT00387465 | 5-Azacytidine |
| HER2-Positive Metastatic Breast Cancer | Phase I Phase II |
NCT01434303 | Lapatinib Trastuzumab |
|
| Acute Lymphoblastic Leukemia Bilineage Biphenotipic leukemia |
Phase I Study | NCT01132573 | Clofarabine | |
| Hodgkin's Lymphoma | Phase 2 | NCT00866333 | ||
| Metastatic Renal Cell Carcinoma | Phase I/II Study | NCT01038778 | Interleukin 2 Aldesleukin |
|
| Breast Cancer | Phase 2 | NCT02115594 | Fulvestrant | |
| Non-Small Lung Cancer, Epigenetic Therapy | Phase 2 | NCT01928576 | Azacitidine CC-486 |
|
| Vorinostat | Neimann-Pick Disease | Phase 1 Phase 2 |
NCT02124083 | |
| Non-Small-Cell Lung Carcinoma | Phase 1 | NCT02151721 | Gefitinib | |
| Von Hippel-Lindau Disease | Phase 1 | NCT02108002 | ||
| Cutaneous T-Cell Lymphoma | Phase 3 | NCT01728805 | Biological: KW-0761 | |
| Gastric Cancer | Phase 1 Phase 2 |
NCT01045538 | capecitabine cisplatin |
|
| Locally Advanced Non-small Cell Lung Cancer | Phase 1 | NCT01059552 | ||
| Sickle Cell Disease Sickle Cell Anemia |
Phase 2 | NCT01000155 | ||
| Panobinostat (LBH589) | Graft-Versus-Host Disease | Phase 1 Phase 2 |
NCT01111526 | |
| Melanoma Skin Cancer |
Phase 1 | NCT02032810 | Ipilimumab | |
| Sickle Cell Disease | Phase 1 | NCT01245179 | ||
| Prostate Cancer Prostatic Neoplasms |
Phase 1 | NCT00878436 | Bicalutamide | |
| Diffuse Large B Cell Lymphoma | Phase 2 | NCT01282476 | Rituximab | |
| Romidepsin Istodax | Lymphoma T-Cell Lymphoma Cutaneous Lymphoma |
Phase 1 | NCT01902225 | Doxil |
| Givinostat | Chronic Myeloproliferative Neoplasms (cMPN) | Phase 2 | NCT01761968 | |
| (Belinostat) (PDX101) | Small Cell Lung Carcinoma Malignant Epithelial Neoplasms |
Phase 1 | NCT00926640 | |
| Neoplasms Lymphomas |
Phase 1 | NCT01273155 | ||
| Pracinostat | Myelodysplastic Syndrome | Phase 2 | NCT01873703 | Azacitidine |
| Valproic Acid | Cancer | Phase 1 | NCT01007695 | |
| High Grade Sarcoma | Phase 1 | NCT01010958 |