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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Transl Res. 2014 Aug 15;165(1):221–240. doi: 10.1016/j.trsl.2014.08.001

Table 3.

HDAC inhibitors ongoing clinical trials

Medication Condition Phase Clinical Trial Other drugs
Etinostat Non-Small Cell Lung Cancer Phase I/II Study NCT00387465 5-Azacytidine
HER2-Positive Metastatic Breast Cancer Phase I
Phase II
NCT01434303 Lapatinib
Trastuzumab
Acute Lymphoblastic Leukemia Bilineage
Biphenotipic leukemia
Phase I Study NCT01132573 Clofarabine
Hodgkin's Lymphoma Phase 2 NCT00866333
Metastatic Renal Cell Carcinoma Phase I/II Study NCT01038778 Interleukin 2
Aldesleukin
Breast Cancer Phase 2 NCT02115594 Fulvestrant
Non-Small Lung Cancer, Epigenetic Therapy Phase 2 NCT01928576 Azacitidine
CC-486
Vorinostat Neimann-Pick Disease Phase 1
Phase 2
NCT02124083
Non-Small-Cell Lung Carcinoma Phase 1 NCT02151721 Gefitinib
Von Hippel-Lindau Disease Phase 1 NCT02108002
Cutaneous T-Cell Lymphoma Phase 3 NCT01728805 Biological: KW-0761
Gastric Cancer Phase 1
Phase 2
NCT01045538 capecitabine
cisplatin
Locally Advanced Non-small Cell Lung Cancer Phase 1 NCT01059552
Sickle Cell Disease
Sickle Cell Anemia
Phase 2 NCT01000155
Panobinostat (LBH589) Graft-Versus-Host Disease Phase 1
Phase 2
NCT01111526
Melanoma
Skin Cancer
Phase 1 NCT02032810 Ipilimumab
Sickle Cell Disease Phase 1 NCT01245179
Prostate Cancer
Prostatic Neoplasms
Phase 1 NCT00878436 Bicalutamide
Diffuse Large B Cell Lymphoma Phase 2 NCT01282476 Rituximab
Romidepsin Istodax Lymphoma
T-Cell Lymphoma
Cutaneous Lymphoma
Phase 1 NCT01902225 Doxil
Givinostat Chronic Myeloproliferative Neoplasms (cMPN) Phase 2 NCT01761968
(Belinostat) (PDX101) Small Cell Lung Carcinoma
Malignant Epithelial Neoplasms
Phase 1 NCT00926640
Neoplasms
Lymphomas
Phase 1 NCT01273155
Pracinostat Myelodysplastic Syndrome Phase 2 NCT01873703 Azacitidine
Valproic Acid Cancer Phase 1 NCT01007695
High Grade Sarcoma Phase 1 NCT01010958