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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Virology. 2014 Nov 14;474:65–81. doi: 10.1016/j.virol.2014.10.033

Fig. 8.

Fig. 8

SCFAs inhibit SIRT1 transcription and induce SIRT1 and EZH2 degradation. (A) Relative levels of EZH2 and SIRT1 mRNAs from 2D10 cells that were treated with fresh medium (Med, control) or filtered Pg supernatant at 1:25 dilution for 6 hours. (B) Western blot detection of SIRT1 and EZH2 proteins from 2D10 cells that were treated with medium (Med) or Pg supernatant at 1:10 dilution in the absence or presence of 2 μM proteasome inhibitor MG-132 and proteasome inhibitor II (P-Inh-II) for 6 hours. Beta-tubulin was used as reference for loading control.

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