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The time-course of antinociception produced after i.t. administration of MMG22 (1 or 10 nmol) in tumor-bearing mice on PID 21. The half-maximal dose effect for 10 nmol was 24 h, whereas mice receiving 1 nmol exhibited half-maximal effect at 4 h. (n = 5/group; **P < 0.01 and ****P < 0.0001